Vol. 7, Issue 2, Part D (2025)

I have studied effect of fuel concentration gradient on autonomous rectification and mobility of Janus particles in confined geometries as well as in presence of interaction with substrates. For this purpose dynamics of an over damped Janus particle in presence of a space dependent self-propulsion have been considered. At first I have calculated the rectification average current and diffusivity of a point like Janus particle in corrugated channel with fixed compartment dimensions where the period of the self-propelled velocity is varying. Next I have calculated the rectification average current and diffusivity of a point like Janus particle in presence of interaction with substrates where each particle interacts with the substrate via a non-periodic potential. The present study provides a better understanding of the diffusion phenomenon in such a situation where fuel is distributed in homogeneously. Biological channel is an example of perfectly inhomogeneous medium. Thus, when, one attempts to transfer a Janus particle through such channel to a targeted place for drug delivery, particles diffuse in a medium where fuels are non-uniform. Thus, present study could motivate researcher to utilize Janus swimmers in medical sciences. It can help the experimentalists to fix the appropriate shape and size of the microwswimmers while guiding them through biological channel in the purpose of targeted drug delivery.